Systems in the System Tree are typically identified with their unique MAC address. But, when systems connect over a VPN they can become associated with the MAC address of the VPN server instead. This can create problems when multiple systems are all connecting through the same VPN. To resolve this, Trellix recommends using the Client GUID to uniquely identify systems that use a VPN.
How systems are associated with a MAC address
The following diagram shows how two systems can be associated with the same MAC address in ePO - On-prem.
Client A connects to ePO - On-prem over the VPN connection.
ePO - On-prem associates the MAC address of the VPN server, 00:12:3F:11:11:11, to Client A rather than the client's actual MAC address.
Client B connects to ePO - On-prem over the VPN connection.
ePO - On-prem associates the MAC address of the VPN server, also 00:12:3F:11:11:11, to Client B. Now two clients have the same VPN server MAC address.
As a result, Client A is deleted from the System Tree because both clients are associated with the same MAC address.

Preventing MAC address conflicts by using the client GUID instead
To resolve this issue, Trellix recommends using client GUIDs instead of MAC addresses to uniquely identify systems.
First, find the Organizationally Unique Identifier (OUI) of the VPN server. The OUI is the first six digits of the MAC address.
Add the VPN server OUI to the virtual MAC vendor values. This change allows ePO - On-prem to identify the VPN server and begin using the client GUID as the unique identifier for systems that connect through it.