Use the Settings > Email MTA page to configure domains and next-hop IP addresses.
The Current Domain and Next-Hop section of the page lists all defined domains.

The Domain and Next-Hop section of the page is used to add or update the configuration of a domain and next-hop IP addresses that are used to deliver emails and notices.

Note
This procedure describes the minimal configuration. For information about other settings, including domains that forward to multiple MTA hosts, see the Email Security — Server User Guide.
Click the Settings page.
Click Email MTA in the sidebar.
Enter the domain name in the Domain box.
Enter the final email host in the Next-hop box.
Click Add.