Before you deploy Agent Handlers in your extended network, consider the health of your existing ePO - On-prem server and database hardware. If this hardware is already overloaded, adding Agent Handlers actually decreases ePO - On-prem performance.
A fully configured Agent Handler has about the same hardware and database requirements as a ePO - On-prem server. When determining how many Agent Handlers you need, first examine the database usage. If the database serving your ePO - On-prem server is under a heavy load, adding Agent Handlers does not improve your performance. Upgrade your SQL Server hardware to take advantage of multiple Agent Handlers. If the database is currently running at a moderate to low load, then additional Agent Handlers can help you expand your logical ePO - On-prem infrastructure.
Trellix testing shows that adding Agent Handlers improves performance until your ePO - On-prem database CPU load exceeds 70 percent. Since each Agent Handler adds some overhead, for example database connections and management queries to the database, adding Agent Handlers beyond 70 percent database CPU load does not help performance.